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总之,现已证实重症抑郁病人枕叶皮质GABA浓度降低,恢复GABA功能对抗抑郁治疗起一定作用,情绪稳定剂可提高癫痫病人皮质GABA浓度,因此GABA系统可能将成为躁郁症未来的治疗靶点。
综上所述,精神药理学、神经影像学、分子神经科学和系统神经科学的实验研究均提示,氨基酸类神经递质系统的功能障碍可能参与情感障碍的发病。因此,氨基酸类神经递质在情感障碍治疗中的作用越来越受到重视。可以预见,谷氨酸能和g氨基丁酸能系统必将成为情感障碍药物治疗研究的新热点。
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[文章编号]1008-0872(2003)02 [中图分类号] [文献标识码] [收稿日期]
[通讯作者]王雪琦 [联系电话](021)25070328-8709 [作者简介]周璇,第二军医大学精神卫生专业本科大三学员。 |
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