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唉小姐别着急,给找来了英文说明书。里面讲严重的撤药反应的发生率也就1%或稍高点,这也不是不可接受的比例,经常还有人出门让车给撞死了,难道就不出门了。再者,说明书强调里了要缓慢停药,如若发生停药反应,要迅速恢复至原有剂量,然后以更缓慢的速度停药。不知道你的例子中举的哪位女士为什么不按照说明书停药。 DiscontinuationofTreatmentwithCymbalta Discontinuationsymptomshavebeensystematically evaluatedinpatientstakingduloxetine. Followingabruptortapered discontinuationinplacebo-controlledclinicaltrials,thefollowingsymptoms occurredat1%orgreaterandatasignificantlyhigherratein duloxetine-treatedpatientscomparedtothosediscontinuingfromplacebo: dizziness,headache,nausea,diarrhea,paresthesia,irritability,vomiting, insomnia,anxiety,hyperhidrosis,andfatigue. DuringmarketingofotherSSRIsandSNRIs(serotoninand norepinephrinereuptakeinhibitors),therehavebeenspontaneousreportsof adverseeventsoccurringupondiscontinuationofthesedrugs,particularlywhen abrupt,includingthefollowing:dysphoricmood,irritability,agitation, dizziness,sensorydisturbances(e.g.,paresthesiassuchaselectricshock sensations),anxiety,confusion,headache,lethargy,emotionallability, insomnia,hypomania,tinnitus,andseizures.Althoughtheseeventsare generallyself-limiting,somehavebeenreportedtobesevere. Patientsshouldbemonitoredforthesesymptomswhen discontinuingtreatmentwithCymbalta.Agradualreductioninthedoserather thanabruptcessationisrecommendedwheneverpossible.Ifintolerablesymptoms occurfollowingadecreaseinthedoseorupondiscontinuationoftreatment, thenresumingthepreviouslyprescribeddosemaybeconsidered.Subsequently, thephysicianmaycontinuedecreasingthedosebutatamoregradualrate |
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