重症抑郁症促炎细胞因子TNF-α的水平显著高 。另外,抑郁症患者有抗炎细胞因子的水平较低。
8周左洛复治疗能够降低见于抑郁症患者一些促炎细胞因子。在抑郁症患者,左洛复增加抗炎细胞因子。
患者中50%以上的响应这样的组合治疗--抗抑郁 + 阿司匹林。在研究结束时80%以上响应消炎的进入缓解。
patients with major depressive disorder had significantly higher levels of the pro-inflammatory cytokine TNF-alpha . In addition, patients with depression had low levels of anti-inflammatory cytokines.
eight weeks of Zoloft treatment was able to decrease some pro-inflammatory cytokines seen in depressed patients. On Zoloft, the depressed patients also saw an increase in anti-inflammatory cytokines.
A study involving depressed patients classified as non-responders supplemented the patients' standard antidepressant treatment with the addition of aspirin, an anti-inflammatory. More than 50% of these patients responded to this combination treatment. At the end of the study more than 80% of the group responsive to the anti-inflammatory went into remission. |