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简单的说,双相患者的大脑结构与非患者不同,某些部位有缺失,服锂可使这些部分“长”出来。
可参考以下文章:
Reduced left anterior cingulate volumes in untreated bipolar patients.Authors: Sassi, Roberto B.1
Brambilla, Paolo2
Hatch, John P.3
Nicoletti, Mark A.3
Mallinger, Alan G.4
Frank, Ellen5
Kupfer, David J.6
Keshavan, Matcheri S.7
Soares, Jair C. soares@uthscsa.eduSource: Biological Psychiatry; Oct2004, Vol. 56 Issue 7, p467-475, 9pDocument Type: ArticleSubject Terms: *AFFECTIVE disorders
*PSYCHOSES
*LITHIUM
*MENTAL illness
*MAGNETIC resonance imaging
*DIAGNOSTIC imaging
TREATMENTAuthor-Supplied Keywords: Affective disorders
bipolar disorder
cingulate
mood disorders
MRI
neuroimaging
Affective disorders
bipolar disorder
cingulate
mood disorders
MRI
neuroimagingNAICS/Industry Codes: 621512 Diagnostic Imaging CentersAbstract: Functional and morphologic abnormalities of the cingulate cortex have been reported in mood disorder patients. To examine the involvement of anatomic abnormalities of the cingulate in bipolar disorder, we measured the volumes of this structure in untreated and lithium-treated bipolar patients and healthy control subjects, using magnetic resonance imaging (MRI).The volumes of gray matter at the right and left anterior and posterior cingulate cortices were measured in 11 bipolar patients not taking any psychotropic medications (aged 38 ± 11 years, 5 women), 16 bipolar patients treated with lithium monotherapy (aged 33 ± 11 years, 7 women), and 39 healthy control subjects (aged 37 ± 10 years, 14 women). Volumetric measurements were made with T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T, and were done blindly.Using analysis of covariance with age and intracranial volume as covariates, we found that untreated bipolar patients had decreased left anterior cingulate volumes compared with healthy control subjects [2.4 ± .3 cm<sup>3</sup> and 2.9 ± .6 cm<sup>3</sup>, respectively; F(1,58) = 6.4, p = .042] and compared with lithium-treated patients [3.3 ± .5 cm<sup>3</sup>; F(1,58) = 11.7, p = .003]. The cingulate volumes in lithium-treated patients were not significantly different from those of healthy control subjects.Our findings indicate that anatomic abnormalities in left anterior cingulate are present in bipolar patients. Furthermore, our results suggest that lithium treatment might influence cingulate volumes in bipolar patients, which could possibly reflect postulated neuroprotective effects of lithium. [Copyright 2004 Elsevier] |
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