本帖最后由 mal 于 14-7-11 11:08 编辑
(1)所有的第二代抗抑郁药物是同样有效的,
2)抗抑郁药的组合(尤其是TCA+ SSRI)治疗比 使用单一抗抑郁药物更为有效,
3)只有60%的严重抑郁症个体 响应抗抑郁药物,
(4)抗抑郁药物yu积极的安慰剂相比,有相对温和的影响, 主动安慰剂效应导致四分之三重度抑郁症的缓解。
相比于活性安慰剂的40%缓解率,对抗抑郁药物的缓解率是: 轻度抑郁症45%,中度抑郁52%,重度抑郁症的56%
轻度抑郁症的治疗:抗抑郁药物不bi活跃安慰剂更有效;
抗抑郁药物已被证明的好处只有在中度至重度重度抑郁症的治疗。
即使不治疗,严重抑郁症的中位时间为6个月。
(1) all second-generation antidepressant medications are equally effective, (2) treatment with a combination of antidepressant medications (especially TCA + SSRI) is much more effective than treatment with a single antidepressant medication,
(3) only 60% of individuals with major depression respond to antidepressant medication, and
(4) antidepressant medications have relatively modest effects when compared with an active placebo - such as patients seeing their GP for brief counselling. The active placebo effect causes three-quarters of the remission from major depression. When compared to the 40% remission rate on active placebo, the remission rate on antidepressant medicationis 45% for mild depression, 52% for moderate depression, and 56% for severe depression. Since antidepressant medication is no more effective than active placebo for the treatment of mild major depressive disorder; antidepressant medication has proven benefit only in the treatment of moderate to severe major depressive disorder. However, for those whose depression causes marked distress or disability; antidepressant medication dramatically reduces the risk of suicide, and returns the individual back to health, months sooner than would have been the case without treatment. It should be remembered that, even without treatment, the median duration of major depressive disorder is 6 months.
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