该药可引起惊恐发作。建议停药。
喜普妙——选择性的SSRI, 氢溴酸西酞普兰片
【药品名称】
通用名:氢溴酸西酞普兰片
商品名:喜普妙
英文名:Citalopram
本品主要成份:氢溴酸西酞普兰
【不良反应】中文
所观察到氢溴酸西酞普兰的副作用通常很少,很轻微且短暂.最常见的不良反应有:恶心,出汗增多,
流涎减少,头痛和睡眠时间缩短.通常在治疗开始的第一或第二周时比较明显,随着抑郁状态的改善
一般都逐渐消失.在稀有个案中曾观察到癫痫发作.在已存心搏缓慢病人中,心搏过缓可使治疗更复
杂.
【不良反应】英文
http://www.xinyao.com.cn/psychonosema/newdrugs/20050326191510.htm
Side effects and drug interactions
Citalopram is safe and well-tolerated in the therapeutic dose range of 20 to 60 mg/day. Distinct from some other agents in its class, Citalopram exhibits linear pharmacokinetics and minimal drug interaction potential, making it a better choice for the elderly or comorbid patients.[5]
Citalopram can have a number of adverse effects. In clinical trials, over 10% of patients reported fatigue, drowsiness, dry mouth, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, cardiac arrythmia, blood pressure, nausea/vomiting, diarrhea, heightened anorgasmia in females, impotence and ejaculatory problems. In rare cases (around over 1% of cases), some allergic reactions, convulsions, mood changes, anxiety and confusion have been reported. Another uncommon side effect is bruxism (teeth grinding).[6] When you stop using citalopram you may experience a feeling similar to electricity or minor shocks in your upper body and in your hands. This is caused by the chemical changes occuring in your brain and they will pass in time. Occasionally, panic attacks (惊恐发作), thoughts of suicide or self-harm may occur or increase in the first few weeks, before the antidepressant effect starts.[7]
Citalopram and other SSRIs have been shown to cause sexual side effects in some patients, both males and females[8]. Although usually reversible, these sexual side effects can sometimes last for months, years or possibly indefinitely even after the drug has been completely withdrawn. This disorder is known as Post SSRI Sexual Dysfunction.
Citalopram is contraindicated in individuals taking MAOIs. It is considered relatively safe in overdose, although fatal cases of dosages 840 mg to 1960 mg have been reported.[9] |