抗抑郁药和代谢酶的图

kk660

以前看过一张抗抑郁药和相关代谢酶的图   谁知道 谢谢！！

笑对江湖

表格形式不对，再发一次
Antidepressants and their metabolizing enzymes

Generic name	Brand name	Metabolism
Tricyclic antidepressants
amitriptyline	Elavil	CYP1A2/2D6, GT1A1
imipramine	Tofranil	CYP1A2/2C19, GT1A3
clomipramine	Anafranil	CYP1A2/2C19/2D6
desipramine	Norpramin	CYP2D6
doxepin	Sinequan	GT1A3/1A4
nortriptyline	Pamelor	CYP2D6
trimipramine	Surmontil
Selective serotonin reuptake inhibitors (SSRIs)
citalopram	Celexa	CYP2C19/2D6
fluoxetine	Prozac	CYP2D6/3A3/4
fluvoxamine	Luvox	CYP1A2/others
paroxetine	Paxil	CYP2D6/others
sertraline	Zoloft	CYP3A3/4
Monoamine oxidase inhibitors (MAOIs)
phenelzine	Nardil
tranylcypromine	Parnate
Others
maprotiline	Ludomil
amoxapine	Asendin
bupropion	Wellbutrin	CYP2B1/2D6/3A4
mirtazapine	Remeron	CYP2D6
nefazodone	Serzone	CYP3A3/4
trazodone	Desyrel
venlafaxine	Effexor	CYP2D6
reboxetine	Vestra	CYP3A4

CYP = cytochrome P-450; GT = glucuronosyltransferase.

笑对江湖

不知道你说的是不是这个？看这个网页http://professionals.epilepsy.com/page/drugs_antidepress.html

Antidepressants and their metabolizing enzymes

Generic name Brand name Metabolism Tricyclic antidepressants amitriptyline Elavil CYP1A2/2D6, GT1A1 imipramine Tofranil CYP1A2/2C19, GT1A3 clomipramine Anafranil CYP1A2/2C19/2D6 desipramine Norpramin CYP2D6 doxepin Sinequan GT1A3/1A4 nortriptyline Pamelor CYP2D6 trimipramine Surmontil    Selective serotonin reuptake inhibitors (SSRIs) citalopram Celexa CYP2C19/2D6 fluoxetine Prozac CYP2D6/3A3/4 fluvoxamine Luvox CYP1A2/others paroxetine Paxil CYP2D6/others sertraline Zoloft CYP3A3/4 Monoamine oxidase inhibitors (MAOIs) phenelzine Nardil    tranylcypromine Parnate    Others maprotiline Ludomil    amoxapine Asendin    bupropion Wellbutrin CYP2B1/2D6/3A4 mirtazapine Remeron CYP2D6 nefazodone Serzone CYP3A3/4 trazodone Desyrel    venlafaxine Effexor CYP2D6 reboxetine Vestra CYP3A4 CYP = cytochrome P-450; GT = glucuronosyltransferase.

kk660

Generic name 通用名称	Brand name 品牌名称	Metabolism 代谢
Tricyclic antidepressants 三环类抗抑郁药
amitriptyline 阿米替林	Elavil Elavil	CYP1A2/2D6, GT1A1 CYP1A2/2D6，GT1A1
imipramine 米帕明	Tofranil Tofranil	CYP1A2/2C19, GT1A3 CYP1A2/2C19，GT1A3
clomipramine 氯米帕明	Anafranil Anafranil	CYP1A2/2C19/2D6 CYP1A2/2C19/2D6
desipramine 昔帕明	Norpramin Norpramin	CYP2D6 CYP2D6
doxepin 多塞平	Sinequan 多塞平	GT1A3/1A4 GT1A3/1A4
nortriptyline 去甲替林	Pamelor Pamelor	CYP2D6 CYP2D6
trimipramine trimipramine	Surmontil Surmontil
Selective serotonin reuptake inhibitors (SSRIs) 选择性五羟色胺再摄取抑制剂（SSRIs）
citalopram 西酞普兰	Celexa 普兰	CYP2C19/2D6 CYP2C19/2D6
fluoxetine 氟西汀	Prozac 百忧解	CYP2D6/3A3/4 CYP2D6/3A3/4
fluvoxamine 氟伏沙明	Luvox 兰释	CYP1A2/others CYP1A2/others
paroxetine 帕罗西汀	Paxil 帕罗西汀	CYP2D6/others CYP2D6/others
sertraline 舍曲林	Zoloft 左洛复	CYP3A3/4 CYP3A3 / 4
Monoamine oxidase inhibitors (MAOIs) 单胺（单胺氧化抑制剂氧化酶抑制剂）
phenelzine 苯乙	Nardil 肼
tranylcypromine tranylcypromine	Parnate Parnate
Others 其他
maprotiline 马普替林	Ludomil Ludomil
amoxapine 阿莫沙平	Asendin Asendin
bupropion 安非他酮	Wellbutrin Wellbutrin	CYP2B1/2D6/3A4 CYP2B1/2D6/3A4
mirtazapine 米氮平	Remeron 瑞美隆	CYP2D6 CYP2D6
nefazodone 奈法唑酮	Serzone Serzone	CYP3A3/4 CYP3A3 / 4
trazodone 曲唑酮	Desyrel Desyrel
venlafaxine 文拉法辛	Effexor 怡诺思	CYP2D6 CYP2D6
reboxetine 瑞波西汀	Vestra Vestra	CYP3A4 CYP3A4的

CYP = cytochrome P-450; GT = glucuronosyltransferase.

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kk660

辛苦了  谢谢