1.心理治疗 2.抗抑郁剂 < 安慰剂

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Over the yearlong study, 77 percent of participants in the FFT recovered, compared to 65 percent of participants in IPSRT and 60 percent in CBT.


在为期一年的研究中，77％的参与者在FFT恢复，65％的参与者在IPSRT恢复,和60％的参与者在CBT恢复。

FFT: family-focused treatment 以家庭为中心的治疗
IPSRT:interpersonal and social rhythm therapy 人际与社会节律治疗
CBT:cognitive-behavioral therapy  认知行为疗法

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抗抑郁剂 < 安慰剂
For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more effective than a placebo


对于正在服用情绪稳定剂的抑郁的人(患有躁郁症)，加入一种抗抑郁药物并不比加入安慰剂更有效


Of the 179 participants who received an antidepressant in addition to a mood stabilizer, 24 percent achieved a durable recovery (at least eight weeks with no more than two depressive or two manic symptoms), compared with 27 percent of the 187 participants who took a mood stabilizer plus placebo. Moreover, adding an antidepressant did not increase the risk of a switch to mania or hypomania. The similar rates of durable recovery indicate that the addition of an antidepressant medication to adequate, optimally dosed mood-stabilizing medications does not improve recovery from bipolar depression any more than adding a placebo.


收到抗抑郁药(+mood stabilizer)的179名参与者中，24％实现了持久的复苏 .
收到安慰剂(+mood stabilizer)的187名参与者中,  27％实现了持久的复苏 。

此外，加入一种抗抑郁药并不增加躁狂或轻躁狂的风险.
添加一种抗抑郁药物, 不会比加安慰剂更有效。



Bupropion (sustained-release formula) and paroxetine are commonly used for patients with bipolar-related depression.

安非他酮和帕罗西汀通常用于治疗双相相关的抑郁症。

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可见抗抑郁药的作用？