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标题: 服锂的必要性 [打印本页]

作者: hahaha1973 时间: 09-1-12 23:07
标题: 服锂的必要性
简单的说，双相患者的大脑结构与非患者不同，某些部位有缺失，服锂可使这些部分“长”出来。
可参考以下文章：

Reduced left anterior cingulate volumes in untreated bipolar patients.Authors: Sassi, Roberto B.1
Brambilla, Paolo2
Hatch, John P.3
Nicoletti, Mark A.3
Mallinger, Alan G.4
Frank, Ellen5
Kupfer, David J.6
Keshavan, Matcheri S.7
Soares, Jair C. soares@uthscsa.eduSource: Biological Psychiatry; Oct2004, Vol. 56 Issue 7, p467-475, 9pDocument Type: ArticleSubject Terms: *AFFECTIVE disorders
*PSYCHOSES
*LITHIUM
*MENTAL illness
*MAGNETIC resonance imaging
*DIAGNOSTIC imaging
TREATMENTAuthor-Supplied Keywords: Affective disorders
bipolar disorder
cingulate
mood disorders
MRI
neuroimaging
Affective disorders
bipolar disorder
cingulate
mood disorders
MRI
neuroimagingNAICS/Industry Codes: 621512 Diagnostic Imaging CentersAbstract: Functional and morphologic abnormalities of the cingulate cortex have been reported in mood disorder patients. To examine the involvement of anatomic abnormalities of the cingulate in bipolar disorder, we measured the volumes of this structure in untreated and lithium-treated bipolar patients and healthy control subjects, using magnetic resonance imaging (MRI).The volumes of gray matter at the right and left anterior and posterior cingulate cortices were measured in 11 bipolar patients not taking any psychotropic medications (aged 38 ± 11 years, 5 women), 16 bipolar patients treated with lithium monotherapy (aged 33 ± 11 years, 7 women), and 39 healthy control subjects (aged 37 ± 10 years, 14 women). Volumetric measurements were made with T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T, and were done blindly.Using analysis of covariance with age and intracranial volume as covariates, we found that untreated bipolar patients had decreased left anterior cingulate volumes compared with healthy control subjects [2.4 ± .3 cm3 and 2.9 ± .6 cm3, respectively; F(1,58) = 6.4, p = .042] and compared with lithium-treated patients [3.3 ± .5 cm3; F(1,58) = 11.7, p = .003]. The cingulate volumes in lithium-treated patients were not significantly different from those of healthy control subjects.Our findings indicate that anatomic abnormalities in left anterior cingulate are present in bipolar patients. Furthermore, our results suggest that lithium treatment might influence cingulate volumes in bipolar patients, which could possibly reflect postulated neuroprotective effects of lithium. [Copyright 2004 Elsevier]

作者: hahaha1973 时间: 09-1-12 23:12
文章2：服锂的双相患者大脑灰质部分增加

Increased gray matter volume in lithium-treated bipolar disorder patients.Authors: Sassi, Roberto B.1,2
Nicoletti, Mark1,3
Brambilla, Paolo1,3,4
Mallinger, Alan G.1,5
Frank, Ellen1,6
Kupfer, David J.1,7
Keshavan, Matcheri S.1
Soares, Jair C.1,3 soares@uthscsa.eduSource: Neuroscience Letters; Aug2002, Vol. 329 Issue 2, p243, 3pDocument Type: ArticleSubject Terms: *LITHIUM
*MANIC-depressive illness
*METHYL aspartateAuthor-Supplied Keywords: Bipolar disorder
Gray matter
Lithium
Magnetic resonance imaging
Mood disorders
NeuroimagingAbstract: Lithium's neurotrophic effects have been reported in several in vitro and ex vivo studies. Preliminary human studies with magnetic resonance imaging (MRI) and spectroscopy have recently provided evidence of lithium-induced increases in gray matter volumes and N-acetyl-aspartate levels. In order to further examine the hypothesis that lithium treatment would relate to detectable increases in gray matter brain content, we blindly measured gray and white matter volumes in MRI images of 12 untreated and 17 lithium-treated bipolar patients and 46 healthy controls. Using multivariate analysis of covariance with age and gender as covariates, we found that total gray matter volumes were significantly increased in lithium-treated (747.9±69.8 cm3) compared with untreated patients (639.2±91.2 cm3; <f>F=10.6</f>; <f>d.f.=1, 25</f>; <f>P=0.003</f>) and healthy individuals (675.8±61.8 cm3; <f>F=17.4</f>; <f>d.f.=1, 59</f>; <f>P<0.001</f>), suggesting in vivo effects of lithium on gray matter, which could possibly reflect lithium's neurotrophic effects. [Copyright 2002 Elsevier]

作者: hahaha1973 时间: 09-1-12 23:18
文章3
大意是：
在双相患者长期服锂后，双边海马部位的脑量增加
Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study.
Images

Go to all 6 images >>Authors:Yucel, Kaan1
McKinnon, Margaret C.1
Taylor, Valerie H.1
Macdonald, Kathryn1
Alda, Martin2
Young, L. Trevor3
MacQueen, Glenda M.1 macqueng@mcmaster.ca
Source

sychopharmacology Dec2007, Vol. 195 Issue 3, p357 11p.
Language:English
Subject Terms:HIPPOCAMPUS (Brain)
MANIC-depressive illness
MEMORY
VERBAL learning
LITHIUM
Keyword(s):Bipolar disorder; Hippocampus; Lithium; Longitudinal; Memory; MRI; Volume
Abstract:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies. In particular, treatment with lithium may exert long-term effects on hippocampal volume, influencing cognitive outcomes in BD patients. To our knowledge, no longitudinal volumetric study has been performed in patients with BD, which would allow for an examination of whether lithium therapy used to treat BD can exert a long-term effect on hippocampal volume. We examined the effects of lithium on hippocampal volumes and recollective memory performance over a period of 2 to 4 years in 12 patients with BD who had never received pharmacotherapy before lithium initiation. We found bilateral increases in volume of the hippocampus over time. We also found some evidence of improvement in verbal memory performance over the 4-year measurement period as assessed by the California Verbal Learning Test. Consistent with preclinical literature supporting the neuroprotective effects of lithium, long-term treatment is associated with preservation of recollective memory function and increased hippocampal size in vivo. ABSTRACT FROM AUTHOR

作者: 销魂流星 时间: 09-1-13 12:36
好厉害，谢谢，请问你目前服锂吗

作者: 销魂流星 时间: 09-1-13 12:37
抗癫痫的心境稳定剂应该没有这个功效吧

作者: 放开你的手 时间: 09-1-13 19:58
标题: 回复 5# 销魂流星的帖子
你们说的是碳酸锂吧，我问过医生，她告诉我说现在这种药医院已经开始禁止了，说有毒素。

作者: 销魂流星 时间: 09-1-13 22:07

原帖由 放开你的手 于 09-1-13 19:58 发表
你们说的是碳酸锂吧，我问过医生，她告诉我说现在这种药医院已经开始禁止了，说有毒素。

谢谢，可是我看书上说碳酸锂是抗躁狂的首选啊

作者: hahaha1973 时间: 09-1-13 22:33
标题: 回复 4# 销魂流星的帖子
是的。

作者: hahaha1973 时间: 09-1-13 22:36
标题: 回复 6# 放开你的手的帖子
这个医生很荒谬。
碳酸锂在美国用得很广泛，当然过量会有副作用，任何药物过量都不好

作者: 鬼妞慧儿 时间: 09-1-13 22:40
终生服药。

作者: hahaha1973 时间: 09-1-13 22:52
继续找相关的最新研究

文章5

服锂双相患者皮层灰质密度增加

Greater Cortical Gray Matter Density in Lithium-Treated Patients with Bipolar Disorder.
Authors:Bearden, Carrie E.1 cbearden@mednet.ucla.edu Thompson, Paul M.2 Dalwani, Manish3 Hayashi, Kiralee M.2 Lee, Agatha D.2 Nicoletti, Mark3 Trakhtenbroit, Michael3 Glahn, David C.3,4 Brambilla, Paolo5 Sassi, Roberto B.6 Mallinger, Alan G.7 Frank, Ellen7 Kupfer, David J.7 Soares, Jair C.3,4,8 Source:Biological Psychiatry; Jul2007, Vol. 62 Issue 1, p7-16, 10p Document Type:Article Subject Terms:*PERIAQUEDUCTAL gray matter *MANIC-depressive illness *NEUROPHYSIOLOGY *BRAIN -- Physiology *BRAIN -- Research *BRAIN mapping *NEUROSCIENCES Abstract:Background: The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. Methods: We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 ± 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 ± 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations. Results: Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (ROI) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8). Conclusions: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences. [Copyright 2007 Elsevier]

作者: xxf780815 时间: 09-1-13 23:42
锂做一个经典的药，应该是要终身，至少在替代药问世之前。它能有效控制躁狂，还可以治疗和预防抑郁，虽然有很多副作用，但对某部人还是有必要

作者: 浮萍fans 时间: 09-1-14 00:17
晕了，那到底要不要服用碳酸锂啊？

我吃过中毒，很可怕。

但现在还在用少量的碳酸锂，吃不吃好啊

作者: 销魂流星 时间: 09-1-14 15:03

原帖由 放开你的手 于 09-1-13 19:58 发表
你们说的是碳酸锂吧，我问过医生，她告诉我说现在这种药医院已经开始禁止了，说有毒素。

碳酸锂真的被禁止了吗？但是目前很多在服啊，应该没有禁止吧

作者: 温州抑郁了 时间: 15-12-2 22:02
真有这么神奇？

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