[参考文献]
[1] INVERNIZZI RW, GARATTINI S. Role of presynaptic
alpha2-adrenoceptors in antidepressant action:recent
findings from microdialysis studies[J]. Prog
Neuropsychopharmacol Biol Psychiatry,2004,28(5):819-827.
[2] NEUMEISTER A. Tryptophan depletion, serotonin, and
depression: where do we stand?[J]. Psychopharmacology
Bulletin,2003,37(4):99-115,
[3] JAY TM, ROCHER C, HOTTE M, et al. Plasticity at
hippocampal to prefrontal cortex synapses is impaired by
loss of dopamine and stress: importance for psychiatric
diseases[J]. Neurotox Res,2004,6(3):233-244
[4] 王学铭 精神与精神病的生物化学. 第一版[M]. 北京:人民卫生出版社,2002. 352-353
[5] MITTERAUER B. Imbalance of glial-neuronal
interaction in synapses: a possible mechanism of the
pathophysiology of bipolar disorder[J].
Neuroscientist.,2004 Jun,10(3):199-206
[6] SANACORA G, GUEORGUIEVA R, EPPERSON CN, et al
Subtype-specific alterations of gamma-aminobutyric acid
and glutamate in patients with major depression[J]. Arch
Gen Psychiatry, 2004 Jul,61(7):705-713
[7] BLIER P, GOBBI G, HADDJERI N, et al Impact of
substance P receptor antagonism on the serotonin and
norepinephrine systems:relevance to the
antidepressant/anxiolytic response[J]. J Psychiatry
Neurosci,2004 May,29(3):208-218.
[8] HEILIG M, ZACHRISSON O, THORSELL A, et al
Decreased cerebrospinal fluid neuropeptide Y (NPY) in
patients with treatment refractory unipolar major
depression: preliminary evidence for association with
preproNPY gene polymorphism[J]. J Psychiatr Res,2004
Mar-Apr,38(2):113-121.
[9] CAMPBELL S, MACQUEEN G. The role of the hippocampus
in the pathophysiology of major depression[J]. J
Psychiatry Neurosci,2004,29(6): 417-426.
[10] MUKHERJEE K, KNISELY A, JACOBSON L. Partial
glucocorticoid agonist-like effects of imipramine on
hypothalamic-pituitary-adrenocortical activity, thymus
weight, and hippocampal glucocorticoid receptors in male
C57BL/6 mice[J]. Endocrinology,2004, 145 (9): 4185-4191.
[11] HASHIMOTO K, SHIMIZU E, IYO M. Critical role of
brain-derived neurotrophic factor in mood disorders[J].
Brain Res Rev, 2004,45(2):104-114.
[12] HATZINGER M, HEMMETER UM, BRAND S, et al.
Electroencephalographic sleep profiles in treatment
course and long-term outcome of major depression:
association with DEX/CRH-test response[J]. J Psychiatr
Res,2004 Sep-Oct,38(5):453-465.
[13] URRETAVIZCAYA M, MORENO I, BENLLOCH L, et al
Auditory event-related potentials in 50 melancholic
patients: increased N100, N200 and P300 latencies and
diminished P300 amplitude[J]. J Affect Disord,2003
May,74(3):293-297.
[14] KAWASAKI T, TANAKA S, WANG J, et al. Abnormalities
of P300 cortical current density in unmedicated
depressed patients revealed by LORETA analysis of
event-related potentials[J]. Psychiatry Clin
Neurosci,2004 Feb,58(1):68-75.
[15] FOSSAI P,ERGIS AM,ALLILAIRE JF. Executive
functioning in unipolar depression:a review[J].
Encephale,2002,28:97-107
[16] ORTIZ T, PEREZ-SERRANO JM, ZAGLUL C, et al Deficit
of cognitive event-related potentials during a working
task in patients with major depression[J]. Actas Esp
Psiquiatr, 2003 Jul-Aug,31(4):177-181.
The neurobiochemistry and neuroelectrophysiologic
studies of depression
YI Zheng-hui, FANG Yi-ru,WANG Zu-ceng
(Shanghai Mental Health Center;Department of Psychiatry
of Shanghai Second Medical University, SHANGHAI 201108,
China)
[KEY WORDS]
depression;neurobiochemistry;neuroelectrophysiology
[ABSTRACT] The etiology of depression is complicated,
which involves in neurobiochemistry,cognitive function
impairment and neuroelectrophysiologic mechanism. The
neurobiochemics mechanisms of depression,which are
introduced to explain the neurobiology mechanisms of
depression by clinical psychopharmacological and
hitherto presumed the most trustworthy theory , include
neurotransmitters and receptors functional abnormal of
NE,5-HT,DA,Ach,GABA and neuropeptide, also include
endocrinium and neurotrophic factors abnormal.
[REFERENCES]
[1]-[3] See above
[4] WANG XM. The biochemistry of psyche and psychosis.
The first edition[M]. Beijing,The people’s medical
publishing house,2002:352
[5]-[16] See above