自杀是双相障碍患者的巨大的威胁。文献统计报告双相障碍患者中有大约25％－50％会在患病后的某个时间有自杀企图，而有15％－19％的人最终会自杀成功。长期随访研究发现在曾有自杀企图的双相患者中在出现自杀企图之后10年内死于自杀的人达10％。部分文献证据显示双相障碍与单相抑郁的自杀发生率是相当的，2004年SEBoD（Social and Economic Burden of Depression）组织的研究显示我国的自杀率目前为23.23/10万,其中约40%是由抑郁障碍造成，由于自杀每年导致52亿人民币的损失[9]，而美国因自杀导致每年损失高达54亿美元，可见双相障碍自杀造成的损失亦是不容忽视的。
[1] Colin D. Mathers. Global Burden of Disease in 2002: data sources, methods and results. Bulletin of the World Health Organization, 2003: 52-56.
[2] Jose Luis Ayuso-Mateos. Global burden of bipolar disorder in the year 2000. Bulletin of the World Health Organization, 2002: 1.
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[5] Olie JP, Levy E. Manic Episodes: The Direct Cost of a Three-Month Period Following Hospitalization. Eur Psychiatry [J]. 2002, 17:278-286.
[6] de Zelicourt M, Dardennes R, Verdoux H, et al. Frequency of Hospitalizations and Inpatient Care Costs of Manic Episodes in Patients With Bipolar I Disorder in France. Pharmacoeconomics [J]. 2003, 21: 1081-1090.
[7] Stender M, Bryant-Comstock L, Phillips S. Medical Resource Use Among Patients Treated for Bipolar Disorder: A Retrospective, Cross-sectional, Descriptive Analysis. Clin Ther [J]. 2002, 24: 1668-1676.
[8] Goetzel RZ, Hawkins K, Ozminkowski RJ, Wang S. The Health and Productivity Cost Burden of the "Top 10" Physical and Mental Health Conditions Affecting Six Large U.S. Employers in 1999. J Occup Environ Med [J]. 2003, 45: 5-14.
[9] Teh-wei Hu, Yanling He, Mingyuan Zhang, Ningshan Chen. Economic Costs of Depression in China, available at: http://www.sebod.org/# accessed September 9, 2006.
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[12]Wolff N, Perlick DA, et al. Modeling costs and burden of informal caregiving for persons with bipolar disorder. J Ment Health Policy Econ [J]. 2006, 9(2): 99-110.
[13]Fu AZ, Krishnan AA, Harris SD. Bipolar Disorder and the Burden of Depression. The burden of depression patients with bipolar disorder. Program and abstracts of the American Psychiatric Association 2004 Annual Meeting, May 1-6, 2004, New York, NY. Abstract NR556.
[14]Chisholm D, et al. Cost-effectiveness of clinical interventions for reducing the global burden of bipolar disorder. Br J Psychiatry [J]. 2005, 187: 559-67.
[15]Calvert NW, et al. The cost-effectiveness of lamotrigine in the maintenance treatment of adults with bipolar I disorder. J Manag Care Pharm[J]. 2006, 12(4): 322-30 .(完)作者: 红杉树 时间: 14-7-10 18:47
五分之一的双相患者最终自杀成功 难过啊作者: 方圆1 时间: 14-7-10 19:05
这几天总是有人发这些倒霉的文章。作者: 方圆1 时间: 14-7-10 19:06
就不能多发点解决问题的文章？作者: 蓝风 时间: 14-7-10 20:28 本帖最后由 蓝风 于 14-7-10 23:21 编辑
这个的确令人震惊，原来以为非常少的。作者: LQY 时间: 14-7-10 21:15
不错，虽然不怎么鼓舞人心，但介绍的非常详细，同时也让我们知道双相大多是可以治疗的比较好的，并不是绝症，是有希望过上正常人生活的。作者: mal 时间: 14-7-10 22:38
多种医学状况在双相障碍患者人群中不成比例的发生，常见的是心血管病、糖尿病、肥胖、甲状腺病、高血压、高脂血症和丙型肝炎感染，关于这些内科医学疾病与双相障碍之间的关系，正在逐渐形成的一种认识是，双相障碍越来越倾向于被认为是一种包括免疫、内分泌、血管、神经功能等在内的多系统障碍。作者: mal 时间: 14-7-11 00:45 本帖最后由 mal 于 14-7-11 10:18 编辑
Bipolar patients are at higher risk for thyroid disease, migraine headaches, heart disease, diabetes, obesity and other physical illnesses.
双极患者甲状腺疾病，偏头痛，心脏疾病，糖尿病，肥胖症和其它生理疾病的风险较高。
The most frequent disorders that co-occur with Bipolar Disorder are Anxiety Disorders (in 75%) and Alcohol Use Disorder (50%). Other disorders that co-occur are substance use, ADHD, and disruptive, impulse-control, or conduct disorder. Metabolic syndrome and migraine are more common among individuals with Bipolar Disorder than in the general population.
与躁郁症共同出现最常见的疾病是焦虑症（75％）和酒精使用障碍（50％）。共同出现的其他疾病: du pin使用，多动症，和破坏性，冲动控制，或品行障碍。代谢综合征和偏头痛与躁郁症个人之间比在普通人群中更为常见。 作者: sqj1969 时间: 14-7-11 05:46
真是狗嘴里吐不出象牙，文章多好哇，居然有人说三道四！！！作者: mal 时间: 14-7-11 08:40
Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease.
躁郁症患者是过早死亡的高危人群。共患心脑血管疾病是死亡率过高的主要原因，远高于与自杀相关的风险。躁郁症，可以有效地概念化为一种多系统性炎症性疾病。作者: mal 时间: 14-7-11 09:20 本帖最后由 mal 于 14-7-11 09:30 编辑
depression can be considered a systemic illness due to the manifold associated biological changes predisposing to somatic diseases and worsening their prognosis.
抑郁症也算是一种全身性疾病，由于多方面的相关生物学变化诱发躯体疾病和日益恶化的预后。
we will begin to think less of depression as a 'mental illness' or even a 'brain disease,' but as a systemic illness,
我们将开始认为抑郁症是一个次要的'精神病'甚至是'脑部疾病， 是全身性疾病，
作者: mal 时间: 14-7-11 09:39
People who have major bouts of depression have an increased risk at a younger age of developing conditions typically associated with getting older. This may be because depression makes cells age prematurely, new research suggests.