Citalopram is safe and well-tolerated in the therapeutic dose range of 20 to 60 mg/day. Distinct from some other agents in its class, Citalopram exhibits linear pharmacokinetics and minimal drug interaction potential, making it a better choice for the elderly or comorbid patients.[5]
Citalopram can have a number of adverse effects. In clinical trials, over 10% of patients reported fatigue, drowsiness, dry mouth, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, cardiac arrythmia, blood pressure, nausea/vomiting, diarrhea, heightened anorgasmia in females, impotence and ejaculatory problems. In rare cases (around over 1% of cases), some allergic reactions, convulsions, mood changes, anxiety and confusion have been reported. Another uncommon side effect is bruxism (teeth grinding).[6] When you stop using citalopram you may experience a feeling similar to electricity or minor shocks in your upper body and in your hands. This is caused by the chemical changes occuring in your brain and they will pass in time. Occasionally, panic attacks （惊恐发作）, thoughts of suicide or self-harm may occur or increase in the first few weeks, before the antidepressant effect starts.[7]
Citalopram and other SSRIs have been shown to cause sexual side effects in some patients, both males and females[8]. Although usually reversible, these sexual side effects can sometimes last for months, years or possibly indefinitely even after the drug has been completely withdrawn. This disorder is known as Post SSRI Sexual Dysfunction.
Citalopram is contraindicated in individuals taking MAOIs. It is considered relatively safe in overdose, although fatal cases of dosages 840 mg to 1960 mg have been reported.[9]作者: ddd12345 时间: 07-3-2 17:01
[quote]原帖由 晔阳 于 07-3-1 22:27 发表
该药可引起惊恐发作。建议停药。
