kk660 发表于 09-10-22 20:40:26

抗抑郁药和代谢酶的图

以前看过一张抗抑郁药和相关代谢酶的图   谁知道 谢谢！！

笑对江湖 发表于 09-10-22 20:40:27

表格形式不对，再发一次
Antidepressants and their metabolizing enzymes

Generic nameBrand nameMetabolismTricyclic antidepressants amitriptylineElavilCYP1A2/2D6, GT1A1imipramineTofranilCYP1A2/2C19, GT1A3clomipramineAnafranilCYP1A2/2C19/2D6desipramineNorpraminCYP2D6doxepinSinequanGT1A3/1A4nortriptylinePamelorCYP2D6trimipramineSurmontilSelective serotonin reuptake inhibitors (SSRIs) citalopramCelexaCYP2C19/2D6fluoxetineProzacCYP2D6/3A3/4fluvoxamineLuvoxCYP1A2/othersparoxetinePaxilCYP2D6/otherssertralineZoloftCYP3A3/4 Monoamine oxidase inhibitors (MAOIs) phenelzineNardiltranylcypromineParnateOthers maprotilineLudomilamoxapineAsendinbupropionWellbutrinCYP2B1/2D6/3A4mirtazapineRemeronCYP2D6nefazodoneSerzoneCYP3A3/4trazodoneDesyrelvenlafaxineEffexorCYP2D6reboxetineVestraCYP3A4CYP = cytochrome P-450; GT = glucuronosyltransferase.

笑对江湖 发表于 09-10-22 22:16:26

不知道你说的是不是这个？看这个网页http://professionals.epilepsy.com/page/drugs_antidepress.html

Antidepressants and their metabolizing enzymes
Generic nameBrand nameMetabolismTricyclic antidepressants amitriptylineElavilCYP1A2/2D6, GT1A1imipramineTofranilCYP1A2/2C19, GT1A3clomipramineAnafranilCYP1A2/2C19/2D6desipramineNorpraminCYP2D6doxepinSinequanGT1A3/1A4nortriptylinePamelorCYP2D6trimipramineSurmontilSelective serotonin reuptake inhibitors (SSRIs) citalopramCelexaCYP2C19/2D6fluoxetineProzacCYP2D6/3A3/4fluvoxamineLuvoxCYP1A2/othersparoxetinePaxilCYP2D6/otherssertralineZoloftCYP3A3/4 Monoamine oxidase inhibitors (MAOIs) phenelzineNardiltranylcypromineParnateOthers maprotilineLudomilamoxapineAsendinbupropionWellbutrinCYP2B1/2D6/3A4mirtazapineRemeronCYP2D6nefazodoneSerzoneCYP3A3/4trazodoneDesyrelvenlafaxineEffexorCYP2D6reboxetineVestraCYP3A4CYP = cytochrome P-450; GT = glucuronosyltransferase.

kk660 发表于 09-10-23 14:52:37

Generic name通用名称 Brand name品牌名称 Metabolism代谢 Tricyclic antidepressants三环类抗抑郁药 amitriptyline阿米替林 ElavilElavil CYP1A2/2D6, GT1A1CYP1A2/2D6，GT1A1 imipramine米帕明 TofranilTofranil CYP1A2/2C19, GT1A3CYP1A2/2C19，GT1A3 clomipramine氯米帕明 AnafranilAnafranil CYP1A2/2C19/2D6CYP1A2/2C19/2D6 desipramine昔帕明 NorpraminNorpramin CYP2D6CYP2D6 doxepin多塞平 Sinequan多塞平 GT1A3/1A4GT1A3/1A4 nortriptyline去甲替林 PamelorPamelor CYP2D6CYP2D6 trimipraminetrimipramine SurmontilSurmontil Selective serotonin reuptake inhibitors (SSRIs)选择性五羟色胺再摄取抑制剂（SSRIs） citalopram西酞普兰 Celexa普兰 CYP2C19/2D6CYP2C19/2D6 fluoxetine氟西汀 Prozac百忧解 CYP2D6/3A3/4CYP2D6/3A3/4 fluvoxamine氟伏沙明 Luvox兰释 CYP1A2/othersCYP1A2/others paroxetine帕罗西汀 Paxil帕罗西汀 CYP2D6/othersCYP2D6/others sertraline舍曲林 Zoloft左洛复 CYP3A3/4CYP3A3 / 4 Monoamine oxidase inhibitors (MAOIs)单胺（单胺氧化抑制剂氧化酶抑制剂） phenelzine苯乙 Nardil肼 tranylcyprominetranylcypromine ParnateParnate Others其他 maprotiline马普替林 LudomilLudomil amoxapine阿莫沙平 AsendinAsendin bupropion安非他酮 WellbutrinWellbutrin CYP2B1/2D6/3A4CYP2B1/2D6/3A4 mirtazapine米氮平 Remeron瑞美隆 CYP2D6CYP2D6 nefazodone奈法唑酮 SerzoneSerzone CYP3A3/4CYP3A3 / 4 trazodone曲唑酮 DesyrelDesyrel venlafaxine文拉法辛 Effexor怡诺思 CYP2D6CYP2D6 reboxetine瑞波西汀 VestraVestra CYP3A4CYP3A4的 CYP = cytochrome P-450; GT = glucuronosyltransferase.
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kk660 发表于 09-10-23 14:53:27

辛苦了谢谢
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