增加帕罗西汀还是米氮平？
医生叫我早上一片帕罗西汀（20毫克），晚上一片米氮平（30毫克），服用两周效果不明显。请问战友现在是增加帕罗西汀还是米氮平？ 加帕罗西汀 阳光达人 发表于 15-7-17 12:48加帕罗西汀
感谢阳光达人。 加小剂量奥氮平好吗？ 楼上的思路是很正确的。当抗抑郁药物不管用的时候可以考虑小剂量地增加非典型抗精神病药，比如奥氮平、阿立哌唑（安律凡）、喹硫平。
我推荐使用2.5—5毫克的安律凡（记住：小剂量的话一定要使用进口版本）。
你可以利用yahoo.com英文搜索引擎输入abilify depression review看看国外用户对安律凡作为增效剂的评价——好评太多了，而且大量的用户竟然有“脱胎换骨”的感受——我觉得这跟小剂量的安律凡有着多巴胺的激动剂效应有关。 能不加最好别加太多种，有时候加了不好减又增加费用 王官庄的 发表于 15-7-17 14:49
楼上的思路是很正确的。当抗抑郁药物不管用的时候可以考虑小剂量地增加非典型抗精神病药，比如奥氮平、阿立 ...
我觉得有些话你不要道听途说，阿立哌唑你吃过吗？确定有抗抑郁作用吗？该药在很多人身上不但没有抗抑郁作用，反而会拉低情绪，另外美国FDA并没有批准阿立哌唑辅助治疗抑郁，只批准治疗躁狂。 楼主，我倒是觉得加米氮平比较合适。最多可以加到60毫克。另外我觉得两周的观察时间有点短，再观察两周再做决定。 四周~六周再评定疗效，时间太短有可能是效果还没出来，耐心一点 我没有道听途说，在国外，阿立哌唑确实在2007年被批准作为抗抑郁药物的增效剂（这是FDA批准的第一个增效剂，以前连碳酸锂都没有批准过。）给你这篇FDA OKs Abilify for Depression看看吧。
具体的链接是http://www.webmd.com/depression/news/20071120/fda-oks-abilify-for-depression 我把英语原文粘贴下来吧，希望英语好的能翻译一下。（此外，在英语的维基百科上也有报道）
FDA OKs Abilify for Depression
Antipsychotic Drug Approved for Use in Addition to Antidepressants for Treating Depression
By Miranda Hitti
WebMD Health News Reviewed by Louise Chang, MD
WebMD News Archive
Nov. 20, 2007 -- The FDA has approved the antipsychotic drug Abilify for treatment of depression when used along with antidepressants.
Abilify isn't a new drug; it was first approved five years ago.
But it's the first drug approved by the FDA as an addition to antidepressants for adults with major depressive disorder, according to Otsuka Pharmaceutical Co. and Bristol-Myers Squibb.
Abilify was discovered by Otsuka Pharmaceutical Company, which partners with Bristol-Myers Squibb to sell Abilify in the U.S. and Europe.
In a news release, the drug companies report that the FDA's latest approval for Abilify was based on two studies that each lasted for six weeks.
Together, the studies included 743 depressed adults whose depression hadn't lifted despite the fact that they were taking antidepressants.
All of the patients kept taking antidepressants during the study. They also took Abilify or a placebo pill, without knowing which was which.
Before-and-after surveys show that the patients taking Abilify got more depression relief than those taking the placebo.
In those studies, Abilify's most common side effects were fidgeting, restlessness, insomnia, constipation, fatigue, and blurred vision.
Earlier this month, the FDA approved Abilify to treat schizophrenia in teens aged 13-17. But Abilify isn't approved to treat depression in children. 王官庄的 发表于 15-7-21 17:28
我没有道听途说，在国外，阿立哌唑确实在2007年被批准作为抗抑郁药物的增效剂（这是FDA批准的第一个增效剂 ...
这个帖你看看
http://www.jfhuzhu.com/forum.php?mod=viewthread&tid=108321&extra=page%3D1 安律凡作为增效剂的用量是2.5-5毫克，远远达不到治疗精神分裂症的10-30毫克。
此外。安律凡作为增效剂需要跟SSRI同时服用。
User Reviews for Abilify你看看
http://www.drugs.com/comments/aripiprazole/abilify-for-depression.html
页:
[1]